NSP4 (rotavirus)

The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It induces diarrhea and causes Ca2+-dependent transepithelial secretion.[1]

References

  1. ^ Dong, Y.; Zeng, CQ; Ball, JM; Estes, MK; Morris, AP (1997). "The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production". Proceedings of the National Academy of Sciences 94 (8): 3960–5. doi:10.1073/pnas.94.8.3960. PMC 20550. PMID 9108087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20550. 
DNA
EBNA-1 · EBNA-2 · EBNA-3 · LMP-1 · LMP-2 · EBER
RNA
VNPs: NSP1 · NSP2 · NSP4 · NSP5 · NSP6

VSPs: E1 · E2

VNPs: P7 · NS2 · NS3 · NS4 · NS5
RT
Fusion protein

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)